Diastolic Function in Chronic Kidney Disease
نویسندگان
چکیده
Abstract Chronic kidney disease (CKD) is characterized by clustered age-independent concentric LV geometry, geometry-independent systolic dysfunction, and age heart rate-independent diastolic dysfunction. Concentric geometry always associated with echocardiographic markers of abnormal relaxation increased myocardial stiffness, two hallmarks Non hemodynamic mechanisms such as metabolic electrolyte abnormalities, activation biological pathways, chronic exposure to cytokine cascade macrophage system also impact structure impair the architecture scaffold, producing increasing reactive fibrosis, altering distensibility. This review addresses pathophysiology diastole in CKD, relations cardiac mechanics, loading, structural conditions, non-hemodynamic factors, characteristics. The three will be examined: elastic recoil, active relaxation, passive distensibility filling. Based on current evidence, we briefly give indications methods for quantification function discuss whether dysfunction represents a distinct characteristic CKD or rather proxy severity cardiovascular condition, potential predicted general phenotype. Finally, discusses opportunity assessment context special emphasis end-stage disease, indicate when in-depth measurements might helpful clinical decision making this context.
منابع مشابه
Diastolic dysfunction and chronic kidney disease
Copyright © 2013 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. pISSN 1226-3303 eISSN 2005-664...
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ژورنال
عنوان ژورنال: Ndt Plus
سال: 2023
ISSN: ['2048-8513', '2048-8505']
DOI: https://doi.org/10.1093/ckj/sfad177